It will be different for each person and a lot of testing what works for you is required. we have tried to a lot of the off the shelf meds but they didn't work for us.
I have know got a prescription from the doc's which works well but I have to take them , one the night before and on in the morning, the retake every 3 hours ( Not the every 4 hours as advised ) as if I wait the 4 hours then I'm over the side making burley.
I have also tried the 1300 sick, and found this to be effective, how ever since my last batch I have been out on the boat
I'm normally good in the river or the bay, but once out the heads is my issue.
few other things I have seen or read about is...but I haven't tried yet
some chemist in Adelaide sells a gel that is used by Paul Worstling ( Ifish )
coke or soft drink before going on the boat as this will calm the gas in the stomach and will make you burp??