I only fish out of the bay so i cant coment on the harbour, but in the bay there are a few general spots that usually produce fish, burley is a must have (i use chook pellets or bread).
common spots to try for bream trev's or kings are:
1.the oil wharf (south side of the bay)
2. the hot water outlet - if you get to the western side of the oil wharf and move south along it you will see the water welling up just south of the fish pen.
3. the sticks, chanel markers west of the point of the oil wharf.
4. the drums, large painted drums (where ships tie up for refueling) just off the point of the wharf.
5. the runways, northern side of the bay, slightly west of the oil wharf
6. moulinoux (spelling?) point, east of the runways
drifting anywhere in the bay usually produces flathead or go out of the bay and troll for bonnies, salmon or kings.
i launch out of the kyeemagh boat ramp, on the cooks river at the end of mutch avenue kyeemagh (it has been upgraded from the pics in the ramps forum)
so there you have it, only basic info and others might give you more detailed info but i hope that helps.